allosteric site sentence in Hindi
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- Therefore, greater GPCR selectivity may be obtained by targeting allosteric sites.
- RNR1 contains both allosteric sites, mediating regulation of substrate specificity and activity.
- However, not all inhibitors that bind at allosteric sites are mixed inhibitors.
- Allosteric sites may represent a novel drug target.
- This may be accomplished by binding to the active site or the allosteric site.
- In addition, sGC contains an allosteric site, to which sGC stimulators bind.
- The second form of " non-competitive antagonists " act at an allosteric site.
- The site to which the effector binds is termed the " allosteric site ".
- Under resting conditions, it is thought that chloride is bound to allosteric sites in prestin.
- These allosteric sites are involved in creating the ligand-enzyme specificity seen in most bioactive enzymes.
- Ketamine appears to inhibit the NMDAR by binding both in the open channel and at an allosteric site.
- Allosteric sites allow effectors to bind to the protein, often resulting in a conformational change involving protein dynamics.
- It also binds to the allosteric site of the serotonin transporter, similarly, but less potently than escitalopram.
- Ganaxolone binds to allosteric sites of the GABA A receptor to modulate and open the hyperpolarization of the neuron.
- In addition to their high substrates such as cocaine and indatraline have lower affinity for these allosteric sites as well.
- The allosteric site of AMP binding on muscle isoforms of glycogen phosphorylase are close to the subunit interface just like Ser14.
- They appear to exert their reuptake inhibition by binding to vaguely characterized allosteric sites on each of the respective monoamine transporters.
- Allosteric sites are pockets on the enzyme, distinct from the active site, that bind to molecules in the cellular environment.
- Allosteric activators such as PEP bind to the same allosteric site and facilitate the formation of the T state, thereby inhibiting enzyme activity.
- For example, when 2, 3-BPG binds to an allosteric site on hemoglobin, the affinity for oxygen of all subunits decreases.
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